Anaphylaxis Review: IM Adrenaline and Angioedema | Part 2 | 過敏 | OET Music

Dr Allison Lu · Pip & Barnaby · Medical English

本頁提供本曲完整英文歌詞與影片搭配的繁中醫學提示。歌詞保留原演唱文字；遇到過度簡化或舊門檻，請搭配下方提示與原始資料閱讀。這是概念學習材料，不替代個別醫療評估。

Lyrics · 完整歌詞

All patients with anaphylaxis receive intramuscular adrenaline 0.5 mg into the thigh first,
lying flat, with antihistamines and steroids as adjuncts only.
Is the swelling painless, non-itchy and unresponsive to antihistamines?
Then suspect bradykinin-mediated hereditary angioedema and check C4.
On re-exposure, allergen cross-links IgE on FcεRI,
releasing histamine immediately and recruiting eosinophils through IL-5 hours later.
Lucid rule for classification:
Graves disease and myasthenia are Type II receptor diseases,
and only Type IV is independent of antibody.

All patients with anaphylaxis receive intramuscular adrenaline 0.5 mg into the thigh first,
lying flat, with antihistamines and steroids as adjuncts only.
Is the swelling painless, non-itchy and unresponsive to antihistamines?
Then suspect bradykinin-mediated hereditary angioedema and check C4.
On re-exposure, allergen cross-links IgE on FcεRI,
releasing histamine immediately and recruiting eosinophils through IL-5 hours later.
Lucid rule for classification:
Graves disease and myasthenia are Type II receptor diseases,
and only Type IV is independent of antibody.

Medical Notes · 醫學學習提示

  1. 非人人0.5 mg：肌注0.01 mg/kg，每次上限0.5 mg
  2. 避免站立行走；抗組織胺與類固醇不能取代腎上腺素
  3. 不癢且抗組織胺無效要留意；遺傳型也可劇烈腹痛
  4. 合驗C4、C1抑制物濃度與功能；正常C4不能完全排除
  5. 再暴露時過敏原交聯FcεRI上的IgE，促使脫顆粒
  6. 組織胺速發；IL-5與嗜酸性球參與遲發相，圖為肥大細胞
  7. 依抗體、免疫複合體或T細胞等效應機轉分類
  8. 葛瑞夫茲病與重症肌無力屬第二型；圖示正常神經肌肉接點
  9. 第四型以T細胞為主；本圖僅示受體位置，非第四型病變
  10. 1 mg/mL溶液：0.01 mg/kg，上限0.5 mg，大腿前外側
  11. 類固醇常規效益未證實；呼吸困難可坐起並伸直雙腿

References