SCID and Conjugate Vaccines: T, B and NK Cells | Part 2 | 免疫 | OET Music

Dr Allison Lu · Pip & Barnaby · Medical English

本頁提供本曲完整英文歌詞與影片搭配的繁中醫學提示。歌詞保留原演唱文字；遇到過度簡化或舊門檻，請搭配下方提示與原始資料閱讀。這是概念學習材料，不替代個別醫療評估。

Lyrics · 完整歌詞

All infants with early Candida, chronic diarrhoea,
pneumonia
and a lymphocyte count below 2.5 × 10⁹/L are investigated urgently for severe combined
immunodeficiency.
Is the child possibly T-cell deficient?
Then no live vaccine, especially rotavirus or BCG,
until immunology has excluded the diagnosis.
On the common gamma chain, X-linked SCID is T-negative, B-positive, NK-negative,
whereas adenosine deaminase deficiency removes all three.
Lucid rule for conjugate vaccines: the protein carrier recruits T-cell help,
so infants make memory IgG against a polysaccharide they could not otherwise remember.

All infants with early Candida, chronic diarrhoea,
pneumonia
and a lymphocyte count below 2.5 × 10⁹/L are investigated urgently for severe combined
immunodeficiency.
Is the child possibly T-cell deficient?
Then no live vaccine, especially rotavirus or BCG,
until immunology has excluded the diagnosis.
On the common gamma chain, X-linked SCID is T-negative, B-positive, NK-negative,
whereas adenosine deaminase deficiency removes all three.
Lucid rule for conjugate vaccines: the protein carrier recruits T-cell help,
so infants make memory IgG against a polysaccharide they could not otherwise remember.

Medical Notes · 醫學學習提示

  1. 嬰兒早發念珠菌感染、慢性腹瀉：警覺免疫缺陷
  2. 反覆或嚴重肺炎也是警訊；插圖為正常肺部
  3. 淋巴球 <2.5×10⁹/L 是警訊，須依月齡判讀
  4. 疑似 SCID 須急查；正常計數也不能排除
  5. 懷疑 T 細胞缺陷：立即轉介免疫專科
  6. 先暫緩活疫苗，尤其輪狀病毒與卡介苗
  7. 由免疫專科評估排除；不可只看外觀
  8. 典型 X 連鎖 SCID：T−B＋NK−；B 細胞仍可失能
  9. ADA 缺乏常為 T−B−NK−，仍有表型差異
  10. 結合型疫苗：蛋白載體招募 T 細胞協助
  11. 促進抗多醣 IgG 與記憶；幼兒純多醣反應較弱

References